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Is there a relationship between serum uric acid and prostate-specific antigen in middle-aged and elderly Chinese men?

  • 0Urology Centre, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
European Journal of Medical Research +

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May 3, 2025

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May 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Serum uric acid (SUA) levels are generally not linked to elevated prostate-specific antigen (PSA) in middle-aged and elderly Chinese men. However, a significant association was found in men aged 75 and older, with high-density lipoprotein cholesterol (HDL-C) potentially modifying this risk.

Area Of Science

  • Urology
  • Endocrinology
  • Nephrology

Background

  • Hyperuricemia is a potential risk factor for prostate cancer development.
  • Elevated serum uric acid (SUA) and prostate-specific antigen (PSA) are common clinical observations.

Purpose Of The Study

  • To evaluate the association between SUA and elevated PSA in middle-aged and elderly Chinese men.
  • To assess the influence of age, glycolipid metabolism, and renal function on this association.

Main Methods

  • Cross-sectional study of 967 Chinese men aged 50 and above.
  • Analysis of blood samples for SUA, PSA, glycolipid metabolism markers, and renal function indicators.
  • Statistical adjustment for age, glycolipid metabolism, and renal function.

Main Results

  • Overall, SUA was not significantly associated with elevated PSA after adjustments (P for trend = 0.259).
  • A significant association was observed in men aged 75 years and older (P for trend = 0.015).
  • High-density lipoprotein cholesterol (HDL-C) significantly interacted with SUA (P = 0.046), with associations stronger in those with high HDL-C.

Conclusions

  • SUA levels are unlikely to be associated with elevated PSA risk in the general middle-aged and elderly Chinese male population.
  • The association between SUA and elevated PSA may be significant in older men (≥75 years).
  • HDL-C levels may modify the relationship between SUA and elevated PSA.

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