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Updated: May 12, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Modification of iridoids in focus: Bridging structural complexity with biological innovation
Maoli Bai1, Honglin Xiang2, Kang Ding2
1School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, PR China; Institute of Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, PR China.
None:
Iridoids, a class of oxygenated monoterpene compounds with a methylcyclopentan-[c]-pyran skeletal, widely exist in plants and microorganisms. Iridoids are mainly classified into cyclopentane iridoids and secoiridoids. The unique structure makes it exhibit varieties of biological activities, such as neuroprotective, anti-tumor, anti-viral, anti-oxidant and anti-inflammatory effects. In order to take a deep dive into the structural properties of iridoid derivatives, as well as to facilitate the development of them, we recapitulate the modification strategies of representative iridoids and biological activities of iridoid derivatives, especially discuss their structure-activity relationship in this review. This article will provide the latest overview and offer insights for structural modification of iridoids in future.
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