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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Solidified ionic liquid-based formulations of metformin with enhanced GI epithelial permeability

Evangelia Tsolaki1, Fiona McCartney2, Anne Marie Healy3

  • 1School of Chemical and Bioprocess Engineering, University College Dublin, Dublin 4, Ireland; SSPC, The Research Ireland Centre for Pharmaceuticals, School of Chemical and Bioprocess Engineering, University College Dublin, Dublin 4, Ireland; EPSRC-SFI Centre for Doctoral Training in Transformative Pharmaceutical Technologies, Ireland.

International Journal of Pharmaceutics
|May 4, 2025
PubMed
Summary

Solidifying active pharmaceutical ingredient-ionic liquids (API-ILs) using spray-encapsulation improves handling and enhances intestinal drug absorption. This novel approach boosts permeability for poorly bioavailable drugs, overcoming formulation challenges.

Keywords:
Active Pharmaceutical Ingredient-Ionic LiquidsEthylcelluloseLabrasol® ALFLipid-based formulationsMetforminMetformin hydrochloridePeceol™PermeabilitySpray-encapsulationcellulose acetatesodium docusate

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