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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

116
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
116
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

257
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
257
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

188
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
188

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Related Experiment Video

Updated: May 9, 2025

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

241

QuantiFERON-TB supernatant-based biomarkers predicting active tuberculosis progression.

Haoxin Xu1, Jingyu Zhou1, Qingluan Yang1

  • 1Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|May 4, 2025
PubMed
Summary
This summary is machine-generated.

New biomarkers show promise in predicting active tuberculosis (TB) development. These markers, including granulocyte-macrophage colony-stimulating factor and vascular endothelial growth factor, outperform interferon-gamma assays for identifying high-risk individuals.

Keywords:
CytokinesDiagnosisImmunological detectionTuberculosis

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Biomarker Discovery

Background:

  • Interferon-gamma release assays have limitations in predicting active tuberculosis (TB) progression.
  • Identifying individuals at high risk for TB development is crucial for early intervention.
  • Silicosis patients are a vulnerable population for TB.

Purpose of the Study:

  • To identify novel biomarkers for predicting the progression from latent tuberculosis infection to active TB (ATB).
  • To compare the predictive accuracy of various cytokines against interferon-gamma (IFN-γ) in TB progressors.

Main Methods:

  • A sub-study of a randomized clinical trial involving silicosis patients (ClinicalTrials.gov: NCT02430259).
  • Analysis of 45 cytokines in QuantiFERON supernatants from 26 active TB (ATB) progressors and 52 matched TB nonprogressors.
  • TB progressors were identified during a 37-month follow-up period.

Main Results:

  • Several cytokines, including granulocyte-macrophage colony-stimulating factor, vascular endothelial growth factor, interleukin (IL)-3, IFN-γ-induced protein 10, IL-10, and IL-9, demonstrated higher predictive value than IFN-γ.
  • These biomarkers showed potential in distinguishing between individuals who progressed to active TB and those who did not.

Conclusions:

  • Novel cytokine biomarkers can significantly improve the prediction of active TB development.
  • These findings support the use of new biomarkers for early identification of individuals at high risk of TB progression.
  • Early intervention strategies can be targeted more effectively using these advanced predictive markers.