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Updated: Sep 7, 2026

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells
Published on: December 31, 2009
A population of lymphocytes in human blood distinctive in morphology and other characteristics
Abstract:
Evidence is presented that lymphocytes characterised by being large and having abundant feebly staining, and usually profusely granulated cytoplasm ('pale' cells) are a group which is distinct from the other small basophilic ('dark') cells. In patients with genetic storage disorders characterised by abnormalities of lymphocyte structure, the structural peculiarites were confined to the basophilic cells, and cytochemical differences were found between the 'pale' and 'dark' cells in normal subjects.
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