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Updated: May 9, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
A critical examination of the relationship between cardiovascular health, cognition, and dementia risk
Joshua L Gills1,2,3, Omonigho M Bubu1,2,3,4
1Department of Psychiatry, Aging Research in Sleep Equity and Dementia Prevention (ARISE-DP) Program, NYU Grossman School of Medicine, New York, NY, USA.
Abstract:
Poor cardiovascular health is strongly linked to increased risk of cognitive impairment and Alzheimer's disease and related dementias. This commentary discusses Yang and associates' work on the associations between cardiovascular health in middle age, as defined by Life Essential 8 scores, and later digital cognitive performance and incident Alzheimer's disease. We examine the strengths and weaknesses of their study within the broader research context. We emphasize the potential significance of sleep and stress the need for longitudinal studies incorporating robust neuropsychiatric methodologies, advanced neuroimaging techniques, and diverse participant samples to enhance the reliability and generalizability of results.
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