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Continuous Inline Magnetic Resonance Relaxometry Measurements on Moving Fluids.

Hans Gaensbauer1,2,3,4, Alexander Bevacqua2,5, Do Hyun Park2

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Nuclear magnetic resonance (NMR) relaxometry can now monitor moving fluids without sample depletion. This new compact coil geometry enables flow-agnostic measurements for manufacturing and reaction monitoring.

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry
  • Chemical Engineering

Background:

  • Nuclear magnetic resonance (NMR) measurements of moving samples are hindered by sample depletion during extended experiments.
  • This limitation restricts the application of NMR relaxometry for monitoring dynamic processes in manufacturing and reactions.
  • Existing postprocessing methods for flow-induced artifacts are ineffective with variable or unknown flow rates, impeding NMR adoption.

Purpose of the Study:

  • To develop a novel NMR coil geometry that eliminates sample depletion effects in measurements of moving fluids.
  • To enable flow-agnostic NMR relaxometry for samples with uncontrolled or variable flow rates.
  • To facilitate real-time process monitoring in industrial and chemical applications.

Main Methods:

  • Design and implementation of a compact NMR coil geometry.
  • Evaluation using relaxometry experiments on fast-flowing water samples.
  • Demonstration of real-time process monitoring capabilities.

Main Results:

  • The developed NMR coil geometry effectively removes the impact of sample depletion on measurements of moving samples.
  • Flow-agnostic NMR measurements were achieved, even with variable and uncontrolled flow rates.
  • Successful real-time monitoring of dairy concentration in a flowing sample was demonstrated.

Conclusions:

  • The novel compact NMR coil geometry overcomes the critical limitation of sample depletion in NMR relaxometry of moving fluids.
  • This advancement significantly broadens the applicability of NMR for process monitoring in manufacturing and chemical reactions.
  • The developed technique offers a robust solution for real-time analysis of dynamic systems with variable flow conditions.