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Published on: December 6, 2016
Causal Associations of Obstructive Sleep Apnea With Cancer Risk: A Mendelian Randomization Study
Xiaoyu He1, Xiaoting Ye2, Kaiqian Yang3
1Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Background:
Observational studies have associated obstructive sleep apnea (OSA) with a higher risk of various cancers; however, causal relationships have not yet been definitively established.
Methods:
Our study evaluated the causal impact of OSA on the risk of developing 22 different types of cancer using univariable and multivariable Mendelian randomization (MR). OSA-associated genetic instruments were obtained from the FinnGen study, which incorporates 38,998 OSA individuals and 336,659 non-OSA individuals from European descent. Summary-level data for 22 site-specific cancers were estimated from large genetic consortia and UK Biobank. We used inverse-variance weighting (IVW) as the primary analysis, along with several sensitivity analyses.
Results:
Univariable MR analyses indicated a causal relationship of genetic susceptibility to OSA on an increased risk of Barrett's esophagus (BE) and esophageal cancer (odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.07-1.62, p = 0.01), endometrial cancer (OR = 1.36, 95% CI = 1.16-1.60, p = 2.26E-04), and its endometrioid subtype (OR = 1.28, 95% CI = 1.04-1.59, p = 0.02). Multivariable MR, accounting for possible confounders like drinking and smoking, confirmed the causal relationships of OSA on BE and esophageal cancer, and endometrial cancer.
Conclusions:
This study provided evidence regarding causal associations of OSA with higher risk of BE and esophageal cancer, and endometrial cancer.
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