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Oncogene Silencing via ecDNA Micronucleation

Lotte Brückner1,2,3, Robin Xu2,3, Jun Tang4,5

  • 1Max Delbrück Center for Molecular Medicine, Berlin, Germany.

Biorxiv : the Preprint Server for Biology
|May 5, 2025
PubMed
Summary

Extrachromosomal DNA (ecDNA) damage, often from replication stress, causes ecDNA to form micronuclei. This process, involving oncogene amplification, impacts tumor genome evolution and treatment resistance.

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