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Stages of Sleep

Stages of Sleep

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Related Experiment Video

Updated: May 9, 2025

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

Sleep Health During Recovery After Stroke.

George D Fulk, Karen J Klingman, Sandra A Billinger

Medrxiv : the Preprint Server for Health Sciences

|May 5, 2025

Summary

This summary is machine-generated.

Stroke survivors with higher depression and lower functional ability experience poorer sleep health. Sleep health remains poor throughout recovery, highlighting potential targets for intervention.

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A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

Published on: November 6, 2019

Area of Science:

Neurology
Sleep Medicine
Rehabilitation Science

Background:

Stroke survivors frequently experience sleep disorders, potentially hindering recovery.
Limited understanding exists regarding overall sleep health (SH) and its post-stroke recovery impact.
Investigating factors associated with SH is crucial for optimizing stroke patient outcomes.

Purpose of the Study:

To explore factors associated with sleep health (SH) during the recovery period following a stroke.

Main Methods:

90 participants without moderate to severe obstructive sleep apnea were assessed at 10, 60, and 90 days post-stroke.
Sleep health was quantified using a composite score from actigraphy and self-report, assessing regularity, satisfaction, alertness, timing, efficiency, and duration.
Associated factors included depression (PHQ-9), cognitive function (MOCA), functional ability (Barthel Index), gait speed, oxygen desaturation index, age, and sex, analyzed via cumulative link mixed model (CLMM).

Main Results:

Higher depressive symptoms (PHQ-9) were significantly associated with poorer sleep health (negative estimate: -0.116, p = 0.0002).
Lower functional ability (Barthel Index) was also significantly linked to poorer sleep health (estimate: 0.016, p = 0.044).
Time elapsed post-stroke did not show a significant association with sleep health.

Conclusions:

Depression and functional ability are significant determinants of sleep health in stroke survivors.
Poor sleep health was prevalent in the hospital and persisted at 60 and 90 days post-stroke.
Further research into the bidirectional relationship between depression/functional impairment and sleep health could identify targets for improving stroke recovery.