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Published on: January 7, 2013
Birth cohort and age-specific trends in global Helicobacter pylori seroprevalence: a scoping review
Chelsea S Taylor1, Mercedes V McMahon1, Zachary J Ward2
1Division of General Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Abstract:
Gastric cancer persists around the world as one of the leading causes of cancer-related death, despite declines in recent years. The declining prevalence of H pylori, the primary risk factor for gastric cancer, has contributed to this reduction and understanding changes in seroprevalence trends over time may yield further insight into gastric cancer incidence trends. We conducted a scoping review to compile data on H pylori seroprevalence in asymptomatic populations to assess global trends by age and birth cohort. We found that published data suggest H pylori seroprevalence declined among recent birth cohorts and increased with age, with trends differing between regions and sub-regions subject to data availability. The Americas lacked sufficient data to enable more robust assessment of H pylori trends by both age and birth cohort.
Funding:
NCI: U01CA265729, P30 CA008748; NIDDK: K08 DK125876.
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