Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review

Area of Science:

• Neuroscience
• Biomedical Engineering
• Neural Engineering

Background:

• Primates have complex central nervous systems and higher intelligence than rodents.
• Understanding primate neural mechanisms is vital for brain disease research, brain-computer interfaces, and AI development.
• Current imaging techniques lack the spatial resolution for deep brain, single-neuron activity detection.

Purpose of the Study:

• To review electrode array devices for deep brain electrophysiological and electrochemical detection in primates.
• To discuss the progress in neural recording and stimulation technologies for primate research.
• To explore the potential of these technologies in neuroscience and clinical applications.

Main Methods:

• Review of electrode array devices for primate deep brain applications.
• Analysis of neural recording and stimulation technologies based on electrode type and device structure.
• Discussion of research progress and future directions.

Main Results:

• Microelectrode technology has advanced for rodent neural studies.
• Primate research requires devices with greater implantation depth, safety, and preparation standards.
• High-resolution, long-term detection devices for primate deep brains are critically needed.

Conclusions:

• Future electrodes require advancements in flexibility, resolution, deep brain penetration, and throughput.
• Improved electrode designs will enhance understanding of deep brain neural activity.
• Developments offer new opportunities and challenges for neuroscience and clinical treatments.