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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Solid-phase synthesis of aryl squaramides using Liebeskind-Srogl cross-coupling
1Department of Organic Chemistry, Faculty of Science, Palacký University 17. listopadu 12 Olomouc 77146 Czech Republic lucie.brulikova@upol.cz.
Abstract:
We present a method for the synthesis of aryl-substituted squaramides through the Liebeskind-Srogl cross-coupling reaction performed on solid support. This approach offers a unique application for the cross-coupling reaction, allowing for the rapid and efficient production of a diverse range of substituted analogs within a combinatorial framework. Through our technique, we successfully synthesized derivatives that were previously unattainable. Additionally, the optimized conditions have been effectively applied in a scale-up reaction. The derivatives show potential for the treatment of drug-resistant tuberculosis.
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