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Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Myasthenia Gravis: Diagnostic Tests01:15

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Disorders of the Skeletal Muscle01:28

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

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The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
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Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
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Inclusion Body Myositis: A Case Report.

Komalpreet Kaur1, Natalie Saliba1, Jitesh Kar2

  • 1Neurology, Edward Via College of Osteopathic Medicine, Auburn, USA.

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|May 5, 2025
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Summary

Inclusion body myositis (IBM) is an autoimmune disease causing muscle weakness. This case report highlights supportive care and physical therapy for managing IBM symptoms and preventing falls in older adults.

Keywords:
autoimmuneidiopathic inflammatory myopathyinclusion body myositismyopathysporadic ibm

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Area of Science:

  • Neurology
  • Immunology
  • Rheumatology

Background:

  • Inclusion body myositis (IBM) is a progressive autoimmune disorder.
  • It is characterized by chronic muscle inflammation and weakness, primarily affecting older adults.

Observation:

  • A 71-year-old male presented with progressive muscle weakness, particularly in finger flexors and quadriceps.
  • The patient experienced frequent falls, a common complication of muscle weakness.

Findings:

  • Muscle biopsy confirmed findings consistent with Inclusion body myositis.
  • The patient's symptoms indicated a typical presentation of IBM.

Implications:

  • Currently, no cure exists for IBM, emphasizing the importance of supportive care.
  • Management strategies include physical therapy and mobility aids to slow disease progression and reduce fall risk.