Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

10.3K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
10.3K
Teeth01:15

Teeth

240
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
240
Pneumothorax-II01:27

Pneumothorax-II

104
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
104
Necrosis01:16

Necrosis

3.6K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
3.6K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

175
The pathophysiology of pneumonia involves the following steps:
175

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TLR4 signaling is activated in ventilator-induced diaphragm dysfunction in rats.

International journal of clinical and experimental pathology·2020
Same author

Silencing of LINC00461 enhances radiosensitivity of lung adenocarcinoma cells by down-regulating HOXA10 via microRNA-195.

Journal of cellular and molecular medicine·2020
Same author

ASCVD risk stratification modifies the effect of HbA1c on cardiovascular events among patients with type 2 diabetes mellitus with basic to moderate risk.

BMJ open diabetes research & care·2020
Same author

Erratum to "The treatment efficacy of galcanezumab for migraine: A meta-analysis of randomized controlled trials" [Clin. Neurol. Neurosurg. 186 (2019) 105428].

Clinical neurology and neurosurgery·2020
Same author

Period 3, a tumor suppressor in non-small cell lung cancer, is silenced by hypermethylation.

International journal of clinical and experimental pathology·2020
Same author

Evaluation of the binding mechanism of iodine with trypsin and pepsin: A spectroscopic and molecular docking.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2020

Related Experiment Video

Updated: May 9, 2025

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

892

Pyroptosis in Pulpitis.

Xiaorui Wei1, Shidian Ran1, Xingrui Yan1

  • 1The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, People's Republic of China.

Journal of Inflammation Research
|May 5, 2025
PubMed
Summary

Pyroptosis, an inflammatory cell death, plays a key role in pulpitis progression. Understanding pyroptosis mechanisms offers new therapeutic targets for dental pulp inflammation.

Keywords:
dental pulp cellspulpitispyroptosis

More Related Videos

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

12.0K
Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

1.5K

Related Experiment Videos

Last Updated: May 9, 2025

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

892
Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

12.0K
Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

1.5K

Area of Science:

  • Oral Biology
  • Immunology
  • Cell Death Research

Background:

  • Pulpitis, an inflammation of dental pulp, can lead to severe dental issues and affect oral health.
  • Pyroptosis, a pro-inflammatory programmed cell death, involves cell membrane rupture and release of inflammatory cytokines.
  • The Gasdermin (GSDM) protein family mediates pyroptosis, crucial for inflammatory responses.

Purpose of the Study:

  • To review the activation mechanisms of pyroptosis in dental pulp.
  • To explore the role of pyroptosis in pulpitis progression.
  • To investigate the interplay between pyroptosis and other regulated cell death (RCD) pathways in dental pulp inflammation.

Main Methods:

  • Literature review of studies on pyroptosis, GSDM proteins, and dental pulp inflammation.
  • Analysis of signaling pathways involved in pyroptosis activation.
  • Examination of the interaction between pyroptosis and other RCD pathways.

Main Results:

  • Pyroptosis activation by various pathways leads to GSDM pore formation, cytokine release (IL-1β, IL-18), and inflammation.
  • Pyroptosis is implicated in the pathogenesis of pulpitis and its progression to apical periodontitis.
  • Interactions with other RCD pathways may modulate the inflammatory response in dental pulp.

Conclusions:

  • Pyroptosis is a significant factor in dental pulp inflammation and warrants further investigation.
  • Targeting pyroptosis pathways presents a promising strategy for novel therapeutic interventions in pulpitis.
  • Understanding pyroptosis offers insights into mechanisms of dental pulp inflammation and potential treatments.