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Epigenetically Regulating Non-coding RNAs in Colorectal Cancer: Promises and Potentials

Zahra Taheri1, Majid Zaki-Dizaji2

  • 1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Middle East Journal of Digestive Diseases
|May 5, 2025
PubMed

Insights

Epigenetic regulation of non-coding RNAs (ncRNAs) plays a crucial role in colorectal cancer (CRC) development, influencing metastasis and drug resistance. Understanding these ncRNAs offers potential for novel CRC diagnostics and targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Colorectal cancer (CRC) presents a significant global health challenge with high mortality rates, often due to metastasis and drug resistance.
  • While genetic alterations are primary drivers, epigenetic modifications are increasingly recognized as critical regulators in cancer development.
  • Non-coding RNAs (ncRNAs) are key epigenetic regulators implicated in the progression of various cancers, including CRC.

Purpose of the Study:

  • To review the role of epigenetically regulated ncRNAs in colorectal cancer development.
  • To elucidate the key regulatory mechanisms involving ncRNAs in CRC.
  • To explore the potential of ncRNAs as biomarkers for CRC diagnosis, prognosis, and therapeutic targets.

Main Methods:

  • Literature review focusing on epigenetics and non-coding RNAs in colorectal cancer.
  • Analysis of studies investigating the functional roles of ncRNAs in CRC progression.
  • Synthesis of current research on ncRNA-mediated epigenetic regulation in CRC.

Main Results:

  • Epigenetically regulated ncRNAs significantly influence CRC initiation, progression, metastasis, and drug resistance.
  • Specific ncRNAs are dysregulated in CRC, impacting key cellular pathways.
  • These ncRNAs demonstrate potential as sensitive and specific biomarkers for CRC.

Conclusions:

  • Epigenetic regulation by ncRNAs is integral to colorectal cancer pathogenesis.
  • Targeting specific ncRNAs offers a promising avenue for novel CRC therapeutic strategies.
  • Further research into ncRNA epigenetics can enhance CRC patient outcomes through improved diagnostics and treatments.
Keywords:
Colorectal cancerDNA methylationEpigeneticEpitranscriptomeNon-coding RNARNA modification

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