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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Cell-Based Therapeutic Strategies for Autoimmune Diseases

Francisco B Quero1, Tays Troncoso-Bravo1, Mónica A Farías1

  • 1Millennium Institute on Immunology and Immunotherapy, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Immunotargets and Therapy
|May 5, 2025
PubMed

Currently, the management of autoimmune disorders still being a challenge in terms of safety, efficiency, and specificity. Cell-based therapeutic strategies have emerged as a novel approach for autoimmune disease treatment, employing different cell therapy platforms, including tolerogenic dendritic cells, regulatory T cells, conventional and regulatory chimeric antigen receptor-T cells, mesenchymal and hematopoietic stem cells, each with their biological features. Here, we discuss the different cell therapy platforms, their immunological mechanisms of action, their therapeutic potential and benefits in autoimmune diseases, and challenges related to their production, scaling up, risks, and patient safety.

Keywords:
CAR T cellautoimmunitycell therapyregulatory T cellstem cellstolerogenic dendritic cell

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