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Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers
Soniya Abraham1, Jay Parekh1, Seohyuk Lee2
1Department of Internal Medicine, Yale-New Haven Health Bridgeport Hospital, Bridgeport, Connecticut, USA.
Aging biomarkers can help predict cancer treatment side effects and personalize therapy. Further research is needed to confirm their clinical use for assessing biological age and patient health.
Area of Science:
- Gerontology and Oncology
- Biomarker Discovery
Background:
- Human aging is a complex process influenced by biological and chronological factors, with biological age reflecting physiological reserve.
- Cancer and its treatments are increasingly recognized as accelerators of biological aging.
- Biomarkers for biological age are crucial for predicting cancer patient outcomes and tailoring treatments.
Purpose of the Study:
- To review current literature on aging biomarkers in cancer patients.
- To focus on cellular senescence and epigenetic modification markers.
- To evaluate biomarkers for predicting chemotherapy and radiation therapy toxicity.
Main Methods:
- Literature review of aging biomarkers in cancer.
- Focus on cellular senescence and epigenetic markers.
- Evaluation of biomarker evidence for predicting treatment toxicity.
Main Results:
- Interleukin-6 (IL-6), leukocyte telomere length (LTL), and DNA methylation age show potential for assessing biological age and frailty.
- p16INK4A expression may predict therapy-induced toxicity and guide treatment decisions.
- Further validation studies are required for clinical application of these biomarkers.
Conclusions:
- Aging biomarkers offer potential for personalized cancer therapy and predicting treatment toxicity.
- Reliability of biomarkers needs further study before clinical integration.
- Biomarkers could aid in individualizing cancer care and managing treatment side effects.
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