Related Experiment Video
Updated: Jul 18, 2026
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Retraction Note: Effect of propofol on myocardial ischemia-reperfusion injury throughMAPK/ERK pathway
Abstract:
The article "Effect of propofol on myocardial ischemia-reperfusion injury through MAPK/ERK pathway" by H.-J. Yan, G.-Q. Qi, Y. Ma published in Eur Rev Med Pharmacol Sci 2019; 23 (24): 11051-11061-DOI: 10.26355/eurrev_201912_19813-PMID: 31858577 has been retracted in accordance with the authors, the Publisher, and the Editor in Chief. The article has been retracted due to inaccurate data and duplicated Western Blots in Figures 2 and 6. The authors acknowledged discrepancies in the published data and were unable to provide the original data, and agreed to the retraction of the manuscript. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/19813.
Insights
This study on propofol and myocardial ischemia-reperfusion injury is retracted due to inaccurate data and duplicated Western Blots. The authors could not provide original data, leading to manuscript retraction.
Area of Science:
- Cardiology
- Pharmacology
- Molecular Biology
Background:
- Myocardial ischemia-reperfusion injury is a significant clinical concern.
- The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway plays a role in cardiac injury.
- Propofol's effects on this pathway warrant investigation.
Purpose of the Study:
- To investigate the effect of propofol on myocardial ischemia-reperfusion injury.
- To explore the involvement of the MAPK/ERK pathway in propofol's action.
Main Methods:
- The study utilized Western Blot analysis to assess protein expression.
- Specific figures (2 and 6) contained duplicated Western Blots, raising data integrity concerns.
Main Results:
- The article reported findings on propofol's effect on myocardial ischemia-reperfusion injury via the MAPK/ERK pathway.
- However, the data presented was found to be inaccurate.
Conclusions:
- The study has been retracted due to significant data integrity issues.
- The authors acknowledged discrepancies and could not provide original data for verification.
