Coding-complete genome sequence of a measles virus genotype B3 isolate from Rabat, Morocco, in 2024

Area of Science:

• Virology
• Genomics
• Epidemiology

Background:

• Measles remains a significant global public health concern.
• Ongoing surveillance is crucial for understanding measles virus evolution and spread.
• Genomic sequencing provides critical insights into viral lineages and transmission patterns.

Purpose of the Study:

• To determine the complete genome sequence of a novel measles virus isolate from Morocco.
• To perform phylogenetic analysis of the identified measles virus.
• To understand the evolutionary relationship of the Moroccan isolate to other known measles virus lineages.

Main Methods:

• Isolation of measles virus from a clinical sample.
• Whole-genome sequencing to obtain the complete genetic code.
• Phylogenetic analysis using established bioinformatics tools and algorithms.

Main Results:

• The coding-complete genome sequence of a measles virus, designated MVi/Rabat.MAR/29.24, was successfully determined.
• Phylogenetic analysis placed the MVi/Rabat.MAR/29.24 isolate within lineage B3.
• The Moroccan isolate demonstrated close genetic relatedness to a previously identified measles virus isolate from the USA.

Conclusions:

• The identification of MVi/Rabat.MAR/29.24 expands the understanding of measles virus diversity in Morocco.
• The close relationship to a USA isolate suggests potential international transmission pathways.
• Continued genomic surveillance is essential for monitoring measles virus evolution and informing public health strategies.