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Updated: May 9, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
Correction: LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
Shuang Qu1, Qiao Liao1, Cheng Yu1
1Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Hypertension Research, Chongqing Cardiovascular Clinical Research Center, Chongqing Institute of Cardiology, Chongqing, China.
This study corrects an image placement error in Figure 4 of a cardiomyocyte regeneration study. The correction ensures accurate representation of the Liver Kinase B1 (LKB1) signaling pathway in heart research.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Regenerative Medicine
Background:
- The study investigates the role of the Liver Kinase B1 (LKB1) signaling pathway in cardiomyocyte regeneration.
- Understanding LKB1's influence is crucial for developing therapies for cardiac repair.
Purpose of the Study:
- To correct an inadvertent image placement error in Figure 4 of a previously published study.
- To ensure the accurate depiction of experimental results concerning LKB1's role in cardiomyocyte regeneration.
Main Methods:
- The correction involved re-examining immunofluorescence images used in the study.
- The mislabeled image for the "LKB1 OE" group was identified and corrected.
Main Results:
- An immunofluorescence image for the "vector" group was mistakenly used for the "LKB1 OE" group in the original Figure 4D1.
- The corrected Figure 4 accurately represents the experimental conditions.
Conclusions:
- The correction of the image placement error does not alter the study's statistical analysis, interpretation, or overall conclusions.
- The findings regarding the LKB1-AMPK-YAP axis in cardiomyocyte regeneration remain valid.
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