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Updated: May 9, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Correction:  LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis

Shuang Qu1, Qiao Liao1, Cheng Yu1

  • 1Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Hypertension Research, Chongqing Cardiovascular Clinical Research Center, Chongqing Institute of Cardiology, Chongqing, China.

Biomolecules & Biomedicine
|May 5, 2025
PubMed

Insights

This study corrects an image placement error in Figure 4 of a cardiomyocyte regeneration study. The correction ensures accurate representation of the Liver Kinase B1 (LKB1) signaling pathway in heart research.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Regenerative Medicine

Background:

  • The study investigates the role of the Liver Kinase B1 (LKB1) signaling pathway in cardiomyocyte regeneration.
  • Understanding LKB1's influence is crucial for developing therapies for cardiac repair.

Purpose of the Study:

  • To correct an inadvertent image placement error in Figure 4 of a previously published study.
  • To ensure the accurate depiction of experimental results concerning LKB1's role in cardiomyocyte regeneration.

Main Methods:

  • The correction involved re-examining immunofluorescence images used in the study.
  • The mislabeled image for the "LKB1 OE" group was identified and corrected.

Main Results:

  • An immunofluorescence image for the "vector" group was mistakenly used for the "LKB1 OE" group in the original Figure 4D1.
  • The corrected Figure 4 accurately represents the experimental conditions.

Conclusions:

  • The correction of the image placement error does not alter the study's statistical analysis, interpretation, or overall conclusions.
  • The findings regarding the LKB1-AMPK-YAP axis in cardiomyocyte regeneration remain valid.

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