Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Occupational Depression Inventory.

Occupational medicine (Oxford, England)·2026

Same author

Laboratory-based turning performance during walking in people with mild cognitive impairment and dementia.

Journal of Alzheimer's disease : JAD·2026

Same author

Microbiome-Directed Therapy for Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Placebo-Controlled Trial of Multistrain Probiotic Supplementation.

The American journal of gastroenterology·2026

Same author

Wearable Inertial Sensor Analysis of Turning Performance Reveals Motor Reserve Effects in Drug-Naïve Parkinson's Disease.

Sensors (Basel, Switzerland)·2026

Same author

Technology Acceptance of 2 mHealth Apps During an Observational Technology Evaluation Study: Qualitative Results of a Mixed Methods Study.

JMIR human factors·2026

Same author

IDEA-FAST clinical study protocol: Identifying digital end-points of fatigue, sleep quality and daytime sleepiness in N = 2000.

Digital health·2026

Search research articles

Related Experiment Video

Updated: Jun 9, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Characterizing Patient-Reported Fatigue Using Electronic Diaries in Neurodegenerative and Immune-Mediated

Adrien Bennetot¹, Rana Zia Ur Rehman², Robbin Romijnders³

¹Let it Care, 11 avenue Marquise du Deffand, Antony, 92160, France, 33 08 92 97 06 43.

JMIR Formative Research

|May 5, 2025

Summary

High-frequency electronic diaries (eDiaries) effectively capture daily fatigue fluctuations in chronic conditions, complementing traditional weekly patient-reported outcomes (PROs) and offering a more detailed understanding of fatigue patterns.

Keywords:

chronic disease diary, patient-reported outcomes digital health digital technologies eHealth electronic diaries fatigue immune-mediated inflammatory diseases mobile phone neurodegenerative diseases

More Related Videos

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Jun 9, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

Area of Science:

Digital Health
Clinical Assessment
Patient-Reported Outcomes

Background:

Fatigue is a common, debilitating symptom in immune-mediated inflammatory diseases (IMIDs) and neurodegenerative diseases (NDDs).
Traditional patient-reported outcomes (PROs) often use long recall periods, missing short-term fatigue variations.
Electronic diaries (eDiaries) offer potential for real-time, granular fatigue data collection.

Purpose of the Study:

To assess the feasibility and acceptability of high-frequency eDiaries for capturing intraday fatigue variability.
To compare eDiary fatigue data with established weekly PROs, specifically the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F).

Main Methods:

A 4-week prospective observational study (IDEA-FAST) involving 159 participants with NDDs, IMIDs, and healthy volunteers.
Participants used eDiaries up to four times daily to report fatigue levels on a 7-point Likert scale.
Adherence was measured, and correlations between averaged eDiary scores and weekly FACIT-F scores were analyzed.

Main Results:

Overall eDiary adherence was 61.99%, with significant variation across disease cohorts.
Clear diurnal fatigue patterns were observed, with higher fatigue reported in the evening (P<.001).
A moderate correlation (Spearman=0.46, P<.001) was found between eDiary and FACIT-F fatigue scores.

Conclusions:

High-frequency eDiaries are feasible, acceptable, and valid for assessing fatigue in chronic conditions.
eDiaries provide complementary data to weekly PROs by capturing intraday and interday fatigue fluctuations.
Future research should focus on optimizing eDiary protocols to balance data richness with participant burden.