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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: May 17, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

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Published on: November 28, 2015

Complex neural-immune interactions shape glioma immunotherapy.

Kun-Wei Song¹, Michael Lim², Michelle Monje³

¹Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA.

|May 5, 2025

Summary

Neural-immune interactions in the central nervous system (CNS) are key for brain health and CNS cancer immunotherapy. Understanding these complex interactions is vital for developing effective brain tumor treatments.

Keywords:

CAR T cells DIPG/DMG brain borders central nervous system glioblastoma immunotherapy

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Last Updated: May 17, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

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Published on: November 28, 2015

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Area of Science:

Neuroimmunology
Cancer Immunology
Central Nervous System (CNS) Malignancies

Background:

The central nervous system (CNS) possesses a unique immunological microenvironment, challenging traditional notions of immune privilege.
Neural-immune interactions significantly influence brain health and the efficacy of cancer immunotherapies.

Purpose of the Study:

To review advancements and obstacles in CNS cancer immunotherapy, focusing on gliomas.
To elucidate the role of neural-immune interactions in shaping immunotherapy strategies for brain and spinal cord tumors.

Main Methods:

Literature review of neural-immune interactions in the CNS.
Analysis of immunotherapy approaches for gliomas.
Examination of challenges in CNS cancer treatment.

Main Results:

The CNS is not immune-privileged; it has distinct immune niches and surveillance mechanisms.
Crosstalk between brain, immune, and tumor cells creates immunosuppressive and neurotoxic environments.
Understanding these interactions is crucial for effective glioma immunotherapy.

Conclusions:

Effective immunotherapy for CNS malignancies requires a comprehensive understanding of neural-immune-tumor cell dynamics.
Future research must address the complexities of the CNS immunological microenvironment to optimize glioma treatments.