Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Recombination00:57

Viral Recombination

23.1K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue-engineered blood vessels for clinical translation: Design logic, representative advances and persistent barriers.

Journal of tissue engineering·2026
Same author

Next-generation strategies for anterior cruciate ligament repair: constructing biointelligent ligament grafts integrating biomimetic design, immune modulation, and sensory feedback.

Frontiers in bioengineering and biotechnology·2026
Same author

Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer.

Nature·2026
Same author

Corrigendum to "Phillyrin ameliorates sepsis via targeting microRNA-203a-mediated caspase-4/caspase-11/caspase-B downregulation to suppress endothelial pyroptosis" [Phytomedicine 152 (2026) 157872].

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Development of a deep learning model to predict cycloplegic myopia and pre- myopia: based on a large-scale screening of school-aged children.

Eye (London, England)·2026
Same author

Ratiometric Fluorescence Biosensor of Allosteric Ag Nanoclusters by G-Quadruplex-Aided Displacement Amplification.

ACS sensors·2026

Related Experiment Video

Updated: May 9, 2025

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation
11:07

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

24.6K

PEBL, a component-based Chinese medicine, reduces virus-induced acute lung injury by targeting FXR to decrease ACE2

Liling Yang1, Xiangjun Zhou2, Junshan Liu3

  • 1Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Department of Pharmacy, Binhaiwan Central Hospital of Dongguan, Dongguan 523900, China.

Journal of Advanced Research
|May 5, 2025
PubMed
Summary
This summary is machine-generated.

Phillyrin-Emodin-Baicalin-Liquiritin (PEBL) effectively treats viral acute lung injury (ALI) by inhibiting the FXR/ACE2 pathway. This component-based Chinese medicine reduces inflammation and improves outcomes in viral pneumonia models.

Keywords:
ACE2Acute lung injuryCytokine stormsFXRPEBLVirus

More Related Videos

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
00:07

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

8.9K
Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.0K

Related Experiment Videos

Last Updated: May 9, 2025

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation
11:07

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

24.6K
A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
00:07

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

8.9K
Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.0K

Area of Science:

  • Pharmacology
  • Immunology
  • Traditional Chinese Medicine

Background:

  • Acute lung injury (ALI) poses a significant clinical challenge with inadequate therapeutic options.
  • Traditional Chinese Medicine (TCM) offers potential, but complex formulations hinder adoption; Component-based Chinese medicine (CCM) presents a viable alternative.
  • Phillyrin-Emodin-Baicalin-Liquiritin (PEBL), a CCM derived from Liang-Ge-San, exhibits anti-inflammatory properties, but its efficacy in viral ALI is unknown.

Purpose of the Study:

  • To investigate the therapeutic effects of PEBL on viral acute lung injury (ALI).
  • To elucidate the underlying molecular mechanisms of PEBL in treating viral ALI.
  • To evaluate PEBL's efficacy in preclinical models of viral respiratory infections.

Main Methods:

  • Assessed PEBL's efficacy in Poly(I:C)-induced ALI models by analyzing cytokine production, macrophage infiltration, lung damage, and mortality.
  • Employed bioinformatics and network pharmacology to identify therapeutic targets and signaling pathways.
  • Validated molecular mechanisms in cell cultures (RAW264.7), zebrafish, and mouse models of Influenza A (PR8) and SARS-CoV-2 Omicron (XBB) induced ALI.

Main Results:

  • PEBL treatment significantly mitigated Poly(I:C)-induced ALI, reducing inflammatory markers and mortality.
  • Virtual screening identified farnesyl X receptor (FXR) and angiotensin-converting enzyme 2 (ACE2) as key targets.
  • PEBL downregulated FXR, inhibiting its binding to ACE2 promoters, suppressing NF-κB activation and subsequent cytokine storm in viral ALI models (PR8 and XBB).

Conclusions:

  • PEBL demonstrates protective effects against viral ALI by inhibiting the FXR/ACE2 signaling axis.
  • PEBL reduces macrophage infiltration, cytokine storm, and inflammatory injury, ameliorating viral ALI.
  • PEBL shows potential as a therapeutic candidate for viral acute lung injury.