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Updated: May 9, 2025
07:42
Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
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Olanzapine for Managing Side Effects From Antiangiogenic Tyrosine-Kinase Inhibitors
Regina M Koch1, Miguel Muniz2, Candy S Peskey2
1Department of Internal Medicine (R.M.K.,), Mayo Clinic, Rochester, Minnesota, USA.
Journal of Pain and Symptom Management
|May 5, 2025
Summary
Olanzapine effectively manages side effects from tyrosine kinase inhibitors (TKIs), including nausea, vomiting, anorexia, and insomnia. This study suggests olanzapine is a promising treatment for these burdensome TKI-induced symptoms.
Area of Science:
- Oncology
- Pharmacology
- Clinical Medicine
Background:
- Tyrosine kinase inhibitors (TKIs) commonly cause burdensome side effects.
- Olanzapine is used for chemotherapy-induced symptoms, but its efficacy for TKI side effects is not well-established.
Purpose of the Study:
- To evaluate the effectiveness of olanzapine in managing TKI-induced nausea, vomiting, anorexia, weight loss, and insomnia.
Main Methods:
- Retrospective review of 60 patients treated with olanzapine and TKIs (lenvatinib, cabozantinib, axitinib, tivozanib) at Mayo Clinic.
- Clinical notes were analyzed for symptom changes (improved, worsened, stable) within three months of initiating olanzapine.
Main Results:
- High rates of improvement were observed: 85% for nausea without vomiting, 93% for nausea with vomiting, 74% for appetite, and 85% for sleep.
- Of patients with prior weight loss, 50% gained weight, and 26% stabilized.
- Only 4 patients discontinued olanzapine due to side effects.
Conclusions:
- Olanzapine demonstrates significant efficacy in alleviating common side effects associated with tyrosine kinase inhibitor therapy.
- Further prospective studies are recommended to confirm these findings and establish olanzapine as a standard treatment option.
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