Testicular changes in rats after administration of organotin complex

Intratesticular administration of di-n-butyltin (o-hydroxyacetophenone S-methyldithiocarbazate) has been shown to induce marked degenerative changes in the testes of adult rats. The possible mechanism of its action is discussed. In particular, an atrophy of seminiferous tubules with complete arrest of spermatogenesis has been noted.