Related Experiment Video
Updated: May 12, 2025
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and
Stefanie Lerche1,2, Isabel Wurster1,2,3, Benjamin Roeben1,2
1Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler‑Strasse 3, 72076, Tuebingen, Germany.
Abstract:
We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PDwildtype) and in 129 samples from PD participants with GBA1 variants (PDGBA1). While Alzheimer profiles increased with age in PDwildtype, it was sparse in PDGBA1. Alpha-Synuclein profiles remained stable with age in both cohorts. In PDwildtype, combined alpha-Synuclein/Alzheimer profiles were associated with earlier onset of cognitive impairment.
More Related Videos
09:27Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
12:01Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
Published on: May 30, 2015
Related Concept Videos
01:26Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
01:37Neural Regulation