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Updated: May 21, 2025
Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Long-term changes in lipid indices following Roux-en-Y gastric bypass: a meta-analysis
Tannaz Jamialahamdi1,2, Elaheh Mirhadi3, Mohammed A Abdalla4,5
1Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Introduction:
Bariatric surgery yields clinically significant long-term weight loss accompanied by marked improvements in numerous weight-related comorbidities including type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, and fatty liver disease.
Objective:
This systematic review and meta-analysis aimed to evaluate the effect of (RYGB) surgery on lipid profile.
Data Source:
We searched PubMed, Scopus, Web of Science and Scholar from inception to May 20th, 2024.
Studies Selection:
Clinical studies that reported lipid profile data with a follow-up of at least 5 years after RYGB were eligible.
Data Extraction:
Two independent reviewers extracted data and assessed the risk of bias.
Results:
Of the 4922 articles identified from our database search, 38 studies that measured lipid profile following RYGB were identified and selected for the analysis. Compared to pre-surgery, at post-surgery follow-up of ≥ 5 years, RYGB was associated with significant reductions in mean total cholesterol (TC) (WMD: - 17.95 mg/dl, 95% CI: - 22.68, - 13.22, 95% PI: - 46.18, 10.27 p < 0.001; I2:92.3), LDL-cholesterol (WMD: - 18.55 mg/dl, 95% CI: -21.85, -15.25, 95% PI: - 39.01, 1.92 p < 0.001; I2:91.8), and triglycerides (WMD: - 60.76 mg/dl, 95% CI: - 66.29, - 55.22, 95% PI: - 91.24, - 30.27 p < 0.001; I2:83.7), and increase in HDL-cholesterol (WMD: 13.75 mg/dl, 95% CI: 12.38, 15.13, 95% PI: 5.32, 22.19 p < 0.001; I2:91.4).
Conclusion:
RYBG is associated with clinically significant large improvements in serum lipids at a post-operative follow-up of 5 years or more.
