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Potential Relationship Between Decreased Serum Selenium Levels and Oxidative Stress in Periodontitis Stage III-IV
Mehmetcan Uytun1, Recep Orbak2, Ahmet Kızıltunç3
1Department of Periodontology, School of Dentistry, Muğla Sıtkı Koçman University, Muğla, 48000, Turkey. mehmetcanuytun@mu.edu.tr.
Biological Trace Element Research
|May 5, 2025
Summary
Periodontitis is linked to increased oxidative stress and lower selenium levels. Selenium may be a key biomarker for periodontal disease, showing a strong correlation with disease severity and oxidative status.
Area of Science:
- Oral Health
- Biochemistry
- Nutritional Science
Background:
- Periodontitis is a prevalent inflammatory disease affecting gums and supporting structures.
- Oxidative stress plays a role in the pathogenesis of various chronic diseases, including periodontitis.
Purpose of the Study:
- To investigate the relationship between periodontitis and markers of oxidative stress: total oxidant status (TOS) and total antioxidant status (TAS).
- To assess the association of serum selenium levels with periodontitis and oxidative stress markers.
Main Methods:
- A case-control study involving 122 participants (61 with periodontitis, 61 healthy controls).
- Measurement of serum TOS, TAS, and selenium levels.
- Statistical analysis including univariate and multivariate logistic regression.
Main Results:
- Periodontitis patients exhibited significantly higher TOS and lower TAS compared to healthy individuals (p < 0.001).
- Serum selenium levels were significantly lower in the periodontitis group (p < 0.001).
- Logistic regression confirmed a significant correlation between lower selenium levels and periodontitis.
Conclusions:
- Periodontitis is associated with an imbalance in oxidative status (elevated TOS, reduced TAS).
- Lower serum selenium levels are significantly correlated with periodontitis.
- Selenium may serve as a valuable biomarker for periodontal disease, reflecting disease activity and oxidative stress.
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