Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study

Peng Qiu ¹, Hongbin Guo ¹, Chao Zhu ²

⁰Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.

European Journal of Medical Research +

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May 5, 2025

View abstract on PubMed

Summary

The atherogenic index of plasma (AIP) is a potential biomarker for abdominal aortic aneurysm (AAA). Higher AIP levels are associated with increased AAA risk in both men and women, aiding in identifying individuals for screening.

Area Of Science

Cardiovascular Medicine
Biomarkers
Epidemiology

Background

Atherosclerosis is a key feature in abdominal aortic aneurysm (AAA) development.
The atherogenic index of plasma (AIP) is a lipid-based marker.
Sex-specific associations between AIP and AAA risk are not well-established.

Purpose Of The Study

To investigate the sex-specific association between AIP and the risk of newly diagnosed AAA.
To evaluate AIP's potential as a biomarker for AAA risk stratification.

Main Methods

Prospective cohort study of 193,013 males and 226,785 females from the UK Biobank.
AIP calculated as log(Triglycerides/HDL-C).
Cox proportional-hazards models used for sex-stratified analyses; AAA identified via codes or death.

Main Results

Over 15.3 years, 1931 male and 424 female AAA cases occurred.
Top AIP quintile associated with increased AAA risk (HR 1.67 males, 1.75 females) vs. bottom quintile.
Smoking modified the association in females; AIP improved AAA prediction models in males and specific female subgroups.

Conclusions

AIP shows potential as a biomarker for abdominal aortic aneurysm.
AIP can help identify high-risk individuals for AAA screening programs.

Keywords:

Abdominal aortic aneurysm Atherogenic index of plasma Atherosclerosis Risk factor Sex