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Related Concept Videos

The JAK-STAT Signaling Pathway01:20

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Related Experiment Video

Updated: May 15, 2025

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
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Microalgae-Based Fucoxanthin Attenuates Rheumatoid Arthritis by Targeting the JAK-STAT Signaling Pathway and Gut

Hui-Ying Xu1, Meng-Ting Jiang1, Yu-Feng Yang2

  • 1Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Journal of Agricultural and Food Chemistry
|May 6, 2025
PubMed
Summary

Fucoxanthin from marine algae effectively treats rheumatoid arthritis (RA) by reducing joint inflammation and restoring gut bacteria. This natural compound targets key inflammatory pathways, offering a promising therapeutic approach for RA management.

Keywords:
JAK-STAT signal pathwayanti-inflammatoryfucoxanthingut microbesrheumatoid arthritis

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Area of Science:

  • Marine Biology
  • Immunology
  • Microbiome Research

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and damage.
  • Fucoxanthin, a marine algae carotenoid, shows potential anti-inflammatory and anticancer properties.
  • Investigating fucoxanthin's therapeutic effects on RA is crucial for developing novel treatments.

Purpose of the Study:

  • To evaluate the therapeutic potential of fucoxanthin from *Phaeodactylum tricornutum* in a collagen-induced rheumatoid arthritis model.
  • To elucidate the underlying mechanisms of fucoxanthin's action in mitigating RA symptoms.

Main Methods:

  • Induction of collagen-induced arthritis in a rodent model.
  • Administration of fucoxanthin extracted from *P. tricornutum*.
  • Assessment of RA symptoms, histological analysis of joints, transcriptomic and metagenomic analyses.

Main Results:

  • Fucoxanthin significantly reduced RA symptoms like joint swelling and weight loss.
  • Histological examination showed decreased synovial inflammation, cartilage damage, and bone erosion.
  • Fucoxanthin suppressed the JAK-STAT pathway, reduced inflammatory cytokines (IL-6, IL-1β), and restored gut microbiota balance.

Conclusions:

  • Fucoxanthin from *P. tricornutum* demonstrates significant therapeutic potential for rheumatoid arthritis.
  • It acts by modulating inflammatory signaling pathways and improving gut microbiota composition.
  • Fucoxanthin represents a promising natural compound for RA management.