Optimization and Characterization of Khellin Loaded Nanogel for the Potential Use in Psoriasis Management
Sehernaz Topuzoğlu1, Evren Algın Yapar2, Lüceyn Abdo1
1Department of Pharmaceutical Technology, Hamidiye Faculty of Pharmacy, University of Health Sciences, Istanbul, Türkiye.
Current Pharmaceutical Biotechnology
|May 6, 2025
Summary
A novel khellin nanogel formulation shows promise for treating psoriasis. This enhanced drug delivery system offers improved skin deposition and accelerated release, potentially improving photochemotherapy efficacy.
Area of Science:
- Pharmaceutical Sciences
- Dermatology
- Nanotechnology
Background:
- Psoriasis is a chronic skin condition impacting quality of life.
- Current psoriasis treatments face challenges like variable response, drug resistance, and side effects.
- Research is ongoing to develop improved therapeutic strategies for psoriasis.
Purpose of the Study:
- To develop and assess a nanogel formulation containing khellin for effective psoriasis treatment.
- To create an advanced drug delivery system for enhanced therapeutic outcomes.
Main Methods:
- Khellin nanogel synthesized using a gelatin-pluronic copolymer via self-assembly.
- Characterization included size, polydispersity index, encapsulation efficiency, in vitro release, and ex vivo skin deposition.
- Formulation evaluated for its potential as a psoriasis treatment delivery system.
Main Results:
- The nanogel exhibited an average size of 119.6 nm with a polydispersity index of 0.248.
- High encapsulation efficiency of 88% was achieved.
- Accelerated drug release within 2 hours and 1.7 times greater skin deposition compared to control gel.
Conclusions:
- The developed khellin nanogel is a promising drug delivery system for psoriasis.
- This formulation holds potential for combination with phototherapy for enhanced psoriasis treatment.
- The nanogel offers an improved therapeutic approach for managing psoriasis.
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