Bioinspired 3D-Printed NIR-Responsive MXene-Based Multifunctional Eutectogel Microneedles for Personalized Infected...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Nanotechnology

Background:

• Infected wound healing presents complex challenges requiring multifaceted therapeutic approaches.
• Current treatments often lack the ability to simultaneously combat infection, promote tissue regeneration, and manage drug delivery effectively.

Purpose of the Study:

• To develop a bioinspired, 3D-printed microneedle patch for advanced infected wound healing.
• To integrate MXene nanosheets and a polymerizable deep eutectic solvent for enhanced therapeutic functions.

Main Methods:

• Fabrication of MXene-based eutectogel microneedles (MF-MXene@MN) using DLP 3D printing with a gradient-height design.
• Incorporation of MXene nanosheets and a polymerizable deep eutectic solvent (PDES) comprising vinyl pyrrolidone (VP), itaconic acid (IA), and N-isopropyl acrylamide (NIPAM).
• Evaluation of photothermal responsiveness, antioxidant activity, and stimuli-triggered drug release (mangiferin).

Main Results:

• Demonstrated significant wound closure (94.88% in 10 days) and enhanced angiogenesis (3.2-fold increase).
• Achieved substantial bacterial reduction (68% overall viability reduction for S. aureus and E. coli under NIR).
• Showcased controlled mangiferin release (88.3% cumulative release) responsive to pH and temperature changes via NIR stimulation.

Conclusions:

• The MF-MXene@MN platform offers a multifunctional solution for infected wound management.
• Bioinspired design, stimuli-responsive materials, and 3D printing enable superior antibacterial efficacy, tissue regeneration, and drug delivery control.
• This innovative approach represents a significant advancement in precision wound care.