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Updated: May 9, 2025
Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
Published on: June 28, 2013
[Research progress of PANoptosis in cancer]
Yi-Ling Luo1,2, Liu-Yan Chen1,2, Yao-Bin Wang1,2
1Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangxi Medical University, Nanning 530021, China.
Abstract:
PANoptosis is a type of programmed cell death regulated by the PANoptosome with key features of pyroptosis, apoptosis and/or necroptosis. As the most complex programmed cell death, PANoptosis emphasizes the compensatory role among multiple programmed cell deaths, and can regulate malignant phenotypes such as proliferation, migration, and invasion of tumor cells through multiple signaling pathways, thus affecting malignant tumor progression. It has been found that PANoptosis plays a dual role in tumor progression and treatment. Therefore, it is clinically important to understand the molecular mechanisms by which PANoptosis affects tumorigenesis, development and progression. This paper reviews the molecular mechanisms of apoptosis, pyroptosis and necroptosis, and discusses the activation and regulation mechanisms of PANoptosis and PANoptosome as well as the research progress on the role of PANoptosis in tumors, aiming to provide new ideas for cancer treatment and prognostic assessment.
Insights
PANoptosis, a complex programmed cell death involving pyroptosis, apoptosis, and necroptosis, impacts tumor progression and treatment. Understanding its mechanisms is crucial for developing novel cancer therapies and improving prognostic assessments.
Area of Science:
- Cellular Biology
- Oncology
- Immunology
Background:
- PANoptosis is a complex programmed cell death pathway regulated by the PANoptosome.
- It integrates features of pyroptosis, apoptosis, and necroptosis.
- PANoptosis plays a significant role in regulating malignant tumor phenotypes and progression.
Purpose of the Study:
- To review the molecular mechanisms of apoptosis, pyroptosis, and necroptosis.
- To discuss the activation and regulation of PANoptosis and the PANoptosome.
- To explore the role of PANoptosis in tumor progression and treatment.
Main Methods:
- Literature review of programmed cell death mechanisms.
- Analysis of signaling pathways involved in PANoptosis.
- Synthesis of current research on PANoptosis in oncology.
Main Results:
- PANoptosis exhibits a dual role in tumor progression and treatment.
- It influences tumor cell proliferation, migration, and invasion.
- Multiple signaling pathways are implicated in PANoptosis-mediated tumor effects.
Conclusions:
- Understanding PANoptosis molecular mechanisms is clinically important for cancer.
- PANoptosis research offers new strategies for cancer treatment.
- PANoptosis could be a target for prognostic assessment in cancer patients.
