[Genotyping and Transfusion Strategy for Pregnant Patients with ABO Blood Typing Difficulties]
Chen-Chen Feng1, Qing Chen2, Xiao Wei3
1Jiangsu Province Blood Center, Nanjing 210042, Jiangsu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|May 6, 2025
Summary
ABO blood group subtypes complicate identification in pregnant individuals. Genetic sequencing accurately determines blood type, ensuring safe transfusions and maternal-fetal health.
Area of Science:
- Hematology
- Genetics
- Obstetrics
Context:
- Pregnant patients often present with challenging ABO blood group typing.
- Accurate blood typing is critical for safe transfusion practices during pregnancy.
Purpose:
- To identify ABO blood group subtypes in pregnant patients with atypical typing.
- To guide safe blood transfusion protocols in this population.
Summary:
- This study analyzed 36 pregnant patients with difficult-to-type ABO blood groups using serological and genetic sequencing methods.
- Twenty ABO subtypes were identified, including various weak A and B variants, cisAB/O, and para-Bombay phenotypes.
- Genetic sequencing proved essential for precise genotype determination, overcoming serological ambiguities.
Impact:
- Accurate ABO blood group genotyping ensures safe blood transfusions for pregnant patients.
- This approach enhances maternal and infant safety by preventing transfusion reactions.
- Highlights the importance of advanced genetic testing in complex obstetric cases.
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