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Updated: May 9, 2025

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
Synthesis of pyridino[2,1-b]quinazolinones via a visible light-induced functionalization of alkynes/nitrile
Minghui Wei1, Xujia Wang1, Jintao Zhang1
1College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, China. guok@njtech.edu.cn.
Abstract:
We successfully developed an unprecedented route to pyridino[2,1-b]quinazolinone synthesis through a visible light-induced functionalization of alkynes/nitrile insertion/cyclization tandem sequences in a microchannel reactor. The yield of the template reaction under optimized conditions is 91%. This photocatalytic reaction provides rapid, facile, and practical access to valuable polycyclic quinazolinone, and is amenable to the gram scale. In addition, a reasonable reaction mechanism is proposed based on controlled experiments.
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