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PLN-related obstructive hypertrophic cardiomyopathy responsive to mavacamten

Matteo Beltrami1, Giacomo Bonacchi2, Maurizio Pieroni3

  • 1Arrhythmia and Electrophysiology Unit, Careggi University Hospital, Largo Brambilla 3, 50135 Florence, Italy.

European Heart Journal
|May 6, 2025
PubMed
Summary

No abstract available in PubMed .

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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
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