A Rare Case of Mammary Analogue Secretory Carcinoma Localized in the Submandibular Gland

Mammary analogue secretory carcinoma (MASC) is a recently described rare salivary gland malignant tumor. A limited number of cases localized in the submandibular gland have been reported. A 56-year-old male patient presented with a slow growing mass in the left neck region. On physical examination, there was a mobile mass measuring approximately 5x4 cm in the left submandibular area. Radiologic imaging revealed a septated cystic mass with peripheral contrast enhancement, containing both solid and fluid components. Fine needle aspiration biopsy (FNAB) result was reported as atypia of uncertain significance. Submandibular gland excision was performed in the first stage. Since the pathology result was MASC and the tumor stage was T3, ipsilateral neck dissection was performed. On histopathological examination, neoplastic cells were seen to be rich in eosinophilic cytoplasm and vacuolization. Immunohistochemical examination revealed cytokeratin 7, mammaglobin and gross cystic disease fluid protein-15 positivity. By presenting this case report, we aimed to add a new case to the already limited number of submandibular gland localized MASC cases in the literature and contribute to the pool of knowledge on this subject. MASC should be considered especially in cases with submandibular gland localization in which the FNAB result is reported as atypia of uncertain significance.