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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...

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Updated: May 9, 2025

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Designing Epigenetic Clocks for Wildlife Research.

Levi Newediuk¹, Evan S Richardson², Alyssa M Bohart³

¹Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Molecular Ecology Resources

|May 6, 2025

Summary

This summary is machine-generated.

Wildlife epigenetic clocks, statistical models predicting age from DNA methylation, are crucial for conservation. This study provides best practices for designing accurate wildlife epigenetic clocks, even with limited samples, aiding conservation efforts.

Keywords:

DNA methylation age estimation biodiversity conservation biomarker epigenetic clock wildlife monitoring

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Last Updated: May 9, 2025

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

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Published on: September 27, 2012

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Published on: July 4, 2018

Area of Science:

Ecology
Genetics
Conservation Biology

Background:

Epigenetic clocks, models predicting age from DNA methylation, are increasingly used in wildlife conservation.
Challenges exist in applying human-developed epigenetic clocks to wildlife due to unreliable chronological ages and limited tissue sampling.
There is a need for field-specific best practices for wildlife epigenetic clock design and validation.

Purpose of the Study:

To provide recommendations for designing and validating accurate epigenetic clocks for wildlife.
To address challenges in applying epigenetic clocks to wildlife, including unreliable age estimates and sampling constraints.
To support the accessible and widespread use of epigenetic clocks in wildlife conservation and management.

Main Methods:

Development of a detailed workflow for designing, validating, and applying wildlife epigenetic clocks.
Utilized simulations and analyses on an extensive polar bear dataset from the Canadian Arctic.
Demonstrated construction and validation of accurate wildlife epigenetic clocks using a limited sample size.

Main Results:

Accurate wildlife epigenetic clocks can be constructed and validated with a limited number of samples.
The proposed workflow accommodates projects with small budgets and sampling constraints.
The study addresses critical concerns for epigenetic clock design in wildlife research.

Conclusions:

The developed workflow enables the creation of accurate epigenetic clocks for wildlife, even with limited resources.
These methods are crucial for advancing the application of epigenetic clocks in wildlife conservation and management.
The study promotes the accessible and widespread use of epigenetic clocks for ecological research and biodiversity protection.