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Published on: September 30, 2021
Physical Function as Assessed by the Liver Frailty Index Remains Stable Over Time in Patients With Hepatocellular
Madeleine D Hu1, Sy Han Chiou2, Molly Delk3
1Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Introduction:
It is unknown how frailty evolves over time in patients with hepatocellular carcinoma who are treated with locoregional therapies (LRTs).
Methods:
We conducted a retrospective study of LRT-treated hepatocellular carcinoma patients with Liver Frailty Index (LFI) assessments. Linear mixed-effects modeling was used to assess the impact of time (modeled linearly per month) and other variables on LFI.
Results:
Of 201 patients enrolled, median baseline LFI was 3.54. LFI did not change significantly over time from study entry ( P = 0.93).
Discussion:
In our study, LFI remained stable over time after LRT, suggesting that LRT is generally well tolerated.
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