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Updated: May 9, 2025
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Long Non-Coding RNA as a Potential Diagnostic Tool in Coronary Artery Diseases - A Systematic Review
As Arthi Sri1,2, V P Veeraraghavan1, S Patil3
1Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Abstract:
Coronary Artery Disease (CAD) remains a leading global health challenge. Long non-coding RNAs (lncRNAs) have emerged as promising biomarkers for CAD. A systematic review following PRISMA guidelines evaluated 22 studies to assess long non-coding RNAs (lncRNAs) as biomarkers for Coronary Artery Disease (CAD). Among 27 identified lncRNAs in 5,301 participants, KCNQ1OT1, HIF1A-AS2, and APOA1-AS showed notable diagnostic accuracy, with 100% sensitivity and 80% specificity. One lncRNA, OTTHUMT00000387022, exhibited the highest specificity at 98%. Despite methodological differences, consistent diagnostic relevance was observed across studies, with sensitivity and specificity reaching 100% and 98%, respectively. This review underscores the potential of lncRNAs as CAD biomarkers, with 23 upregulated and 4 downregulated lncRNAs identified. Their stable presence in human biofluids and strong association with CAD suggest their utility as diagnostic markers and potential therapeutic targets.
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