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Related Experiment Video

Updated: May 10, 2026

A Rapid and Chemical-free Hemoglobin Assay with Photothermal Angular Light Scattering
05:18

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Wearable Photonic Device for Multiple Biomarker Sampling and Detection without Blood Draws.

Zuan-Tao Lin1, Biswabandhu Jana1, Sandeep Korupolu1

  • 1Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston, MA, 02114, USA.

Advanced Materials (Deerfield Beach, Fla.)
|May 6, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a needle-free wearable photonic device for blood biomarker detection. It uses light to enhance biomarker concentration in the skin for painless, sensitive analysis.

Keywords:
microlens arraymicroneedle arraymultiple biomarker detectionmultiple biomarker samplingoptic device

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Area of Science:

  • Biophotonics and Biosensing
  • Minimally Invasive Diagnostics
  • Wearable Health Technology

Background:

  • Traditional phlebotomy involves needles, causing pain and inconvenience.
  • Existing diagnostic methods often lack sensitivity or require invasive procedures.
  • Need for non-invasive, accurate, and user-friendly biomarker detection methods.

Purpose of the Study:

  • To develop a wearable photonic device for needle-free blood biomarker sampling and detection.
  • To enable painless and convenient monitoring of health status through blood biomarkers.
  • To achieve high sensitivity and multiplexed detection of biomarkers.

Main Methods:

  • Integration of a microlens array (MLA) and an optic microneedle array (OMNA) functionalized with immunobinding.
  • Use of 595 nm LED light to enhance biomarker extravasation in the dermis.
  • Specific antibody immobilization on OMNA for targeted biomarker capture and signal amplification.

Main Results:

  • The device successfully amplified and transmitted light into the dermis, independent of skin color.
  • Light illumination increased capillary biomarker concentrations via thermal dilation and extravasation.
  • Demonstrated superior sensitivity compared to enzyme-linked immunosorbent assay (ELISA) kits in mouse models.

Conclusions:

  • The wearable photonic device offers a safe and effective needle-free approach for biomarker sampling.
  • The technology enables precise, minimally invasive, and multiplexed detection of blood biomarkers.
  • Validated in mouse models for quantifying inflammation and antibody production, showing diagnostic potential.