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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

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In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
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Updated: May 1, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
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Real-Time Dose-Guided Radiation Therapy.

Paul J Keall1, Issam El Naqa2, Martin F Fast3

  • 1Image X Institute, University of Sydney, Sydney, Australia.

International Journal of Radiation Oncology, Biology, Physics
|May 6, 2025
PubMed
Summary
This summary is machine-generated.

Real-time dose-guided radiation therapy adapts to the dynamic human body, improving cancer treatment. This approach enhances imaging, dose accumulation, and adaptation, leading to better patient outcomes.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Medical Imaging

Background:

  • Adaptive radiation therapy (ART) has improved prostate cancer treatment by treating tumors as rigid bodies.
  • The human body's dynamic nature presents challenges for traditional radiation therapy.
  • Real-time adaptive approaches are needed to account for anatomical complexity during treatment.

Purpose of the Study:

  • To review the development and potential of dose-guided radiation therapy (DGRT).
  • To explore quasi-continuous volumetric imaging, dose accumulation, and treatment adaptation.
  • To assess clinical evidence and future opportunities for DGRT.

Main Methods:

  • Review of clinical evidence for real-time ART.
  • Description of real-time volumetric imaging (X-ray and MRI).
  • Evaluation of real-time dose accumulation and delivery measurement.
  • Examination of real-time treatment adaptation strategies.

Main Results:

  • Real-time volumetric imaging (X-ray, MRI) is nearing broader implementation.
  • Real-time dose accumulation shows clinical feasibility with real-time approximations.
  • Real-time treatment adaptation to deforming and multiple targets has been demonstrated.
  • Improved patient outcomes correlate with conformal treatment to dynamic anatomy.

Conclusions:

  • Dose-guided radiation therapy offers significant potential for improved patient outcomes.
  • Advances in DGRT are primarily software-driven, enabling cost-effective upgrades.
  • Artificial intelligence can accelerate the adoption of DGRT for wider patient use.