Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

4.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.3K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

7.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.2K
Tumor Progression02:07

Tumor Progression

6.1K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.1K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

11.3K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.3K
Mismatch Repair01:20

Mismatch Repair

4.6K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

616
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
616

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Duration of Spent Mushroom Substrate Return Affects Microbial Assembly and Nitrogen Metabolism to Promote Functional Stabilization in Rice-Mushroom Crop Rotation Systems.

Microorganisms·2026
Same author

Effects of Dietary Protein Levels on Growth, Serum Physiology, Protein and Lipid Metabolism, and Antioxidant Responses in Black Carp (<i>Mylopharyngodon piceus</i>).

Metabolites·2026
Same author

Neoadjuvant immunotherapy in locally advanced head and neck squamous cell carcinoma: From oncologic outcomes to response-adaptive treatment de-escalation.

Critical reviews in oncology/hematology·2026
Same author

A survey in Liangshan, Sichuan showed higher human papillomavirus infection rate and cervical cancer risk for Yi Chinese compared to Han Chinese.

Gynecology and pelvic medicine·2026
Same author

Cooperative protein-ligand antioxidant activation: Sulforaphane binding to human serum immunoglobulin Genhances neuroprotection in spinal cord neurons via structural and functional modifications.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Unlocking the Potential for Genetic Engineering of the Straw-Degrading Mushroom <i>Stropharia rugosoannulata</i> by Constructing a CRISPR/Cas9 Gene Editing System.

Journal of fungi (Basel, Switzerland)·2026

Related Experiment Video

Updated: May 9, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.1K

Germline mutations predispose a concurrent thymoma and diffuse large B-cell lymphoma.

Xiaoyan Fu1, Qiao Jiang1, Wenbin Mo1

  • 1Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

Annals of Hematology
|May 6, 2025
PubMed
Summary

This study investigated concurrent extrathymic diffuse large B-cell lymphoma (DLBCL) and thymoma. Whole-exome sequencing revealed specific genetic alterations, offering insights into the pathogenesis of these co-occurring cancers.

Keywords:
DLBCLGermline mutationSomatic mutationThymomaWhole-exome sequencing

More Related Videos

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

12.2K
Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

9.6K

Related Experiment Videos

Last Updated: May 9, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.1K
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

12.2K
Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

9.6K

Area of Science:

  • Oncology
  • Genetics
  • Pathogenesis

Background:

  • Thymoma, a rare cancer, frequently co-occurs with secondary malignancies.
  • Non-Hodgkin's B-cell lymphoma is a common secondary neoplasm in thymoma patients.
  • The molecular mechanisms underlying thymoma and lymphoma co-occurrence are not well understood.

Observation:

  • A case of concurrent extrathymic diffuse large B-cell lymphoma (DLBCL) and thymoma was reported.
  • Literature review and SEER database analysis summarized features of patients with these concomitant cancers.
  • Whole-exome sequencing (WES) was conducted on tumor and normal tissue samples.

Findings:

  • Distinct germline mutations and somatic alterations were identified in both neoplastic tissues.
  • These genetic findings may shed light on the pathogenesis of concurrent thymoma and DLBCL.
  • This research presents novel findings on concurrent extrathymic DLBCL and thymoma using WES.

Implications:

  • Understanding the genetic basis of concomitant cancers can improve diagnostic and therapeutic strategies.
  • This study contributes to the knowledge of rare cancer co-occurrences.
  • Further research into shared molecular pathways could reveal new therapeutic targets for thymoma and lymphoma.