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Updated: Jun 18, 2026

Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice
Published on: April 15, 2014
The "H sign" in MOGAD myelitis
Santiago Aristizabal Ortiz1,2, Laura Andrea Campaña Perilla3, Angela Patricia Guarnizo Capera3
1Department of Diagnostic Imaging, Fundación Santa Fe de Bogotá, 116 street # 9-02, Bogotá, 110111, Colombia. saristizabal@unbosque.edu.co.
None:
A 40-year-old man presented with acute urinary retention and bilateral lower limb weakness. MRI revealed a longitudinally extensive T2 hyperintense spinal cord lesion from C6 to T10, predominantly involving the gray matter ("H sign"). Brain MRI and CSF studies were unremarkable. Serum MOG-IgG was positive. The patient was treated with intravenous corticosteroids, with subsequent clinical and radiologic improvement. The imaging and clinical findings were consistent with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).
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