Related Experiment Video
Updated: May 9, 2025

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
Published on: March 17, 2023
Regulation of Adipose Tissue Metabolism During Fasting
Philip M M Ruppert1, Sander Kersten2,3
1Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Fasting impacts adipose tissue metabolism by inhibiting fat storage and enhancing fat breakdown. This process mobilizes stored fats and influences their distribution to other body tissues.
Area of Science:
- Metabolic regulation
- Endocrinology
- Adipose tissue biology
Background:
- Fasting is increasingly recognized for its health benefits.
- Understanding adipose tissue's role in fasting is crucial for metabolic health.
- Sexual dimorphism in metabolic regulation warrants specific attention.
Purpose of the Study:
- To review the effects of fasting on adipose tissue metabolism.
- To highlight the sexually dimorphic regulation of these metabolic changes.
- To elucidate the molecular and humoral mechanisms involved.
Main Methods:
- Review of existing literature on fasting and adipose tissue.
- Analysis of humoral factors (insulin, glucagon, hormones, catecholamines).
- Examination of neuronal pathways and gene regulation.
Main Results:
- Fasting suppresses triacylglycerol storage by inhibiting lipoprotein lipase.
- Fasting enhances triacylglycerol breakdown via adipose triglyceride lipase and hormone-sensitive lipase.
- Metabolic shifts are mediated by hormonal, neuronal, and transcriptional factors, showing sexual dimorphism.
Conclusions:
- Fasting significantly alters adipose tissue metabolism, promoting fat mobilization.
- These adaptations involve complex hormonal and neuronal signaling.
- Further research into sexually dimorphic responses can inform therapeutic strategies.
More Related Videos
08:34Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
Related Concept Videos
Metabolic States of the Body: The Postabsorptive State
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Metabolic States of the Body: Fasting and Starvation
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Regulation of Food Intake
Metabolic States of the Body: The Absorptive State
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...