Successful Treatment of Sacral Pressure Injury With ACU-D1

Pressure injuries, previously known as pressure ulcers, commonly affect elderly patients in the sacral area, resulting in a sacral pressure injury. The mainstay of treatment is supportive care, including avoiding further pressure on the wounded area. In our case report, we encountered a patient with a stage 2 pressure injury that was resistant to a month of supportive treatment, with no improvement. After a trial of 10% ACU-D1, a proteasome inhibitor cream, the patient experienced relief in symptoms and complete re-epithelialization of the injury site within one month. With emerging research suggesting a role of inflammation and neutrophil activation in pressure injuries, we propose that further investigation into ACU-D1 for pressure injuries and other chronic wounds could benefit patients. Citation: Huang C, Arbiser JL. Successful treatment of sacral pressure injury with ACU-D1. J Drugs Dermatol. 2025;24(5):534-535. doi:10.36849/JDD.8782.