Research on the effects and related mechanisms of geomagnetic storm on depression
Hui Wu1, Yuan Yang2, Weiyu Chang2
1The Department of Pharmacology, School of Basic Medicine, Kunming Medical University, Kunming, China; Clinical Pharmacy Center, The First Affiliated Hospital of Kunming Medical University, Kunming, China; State Key Laboratory of Neurology and Oncology Drug Development, China.
Objective:
Depression has become disabling disease in the world. Geomagnetic storm is closely related to depression behavior, and melatonin is an important factor in the pathogenesis of depression. This study observed the effects of different intensities of geomagnetic storm on melatonin in depressed rats. Aim to provides a theoretical basis for the prevention and treatment of depression and other melatonin related mental illnesses during geomagnetic storms.
Methods:
In this study, rats with chronic unpredictable mild stress (CUMS) were exposed to geomagnetic storms of different intensities for 7 days. The depressive behavior of CUMS rats was determined via the weigh, sucrose preference test, elevated plus maze test, novelty-suppressed feeding test and open field test. Then, through the use of kits, qPCR analysis, immunofluorescence staining and western blot analysis of melatonin synthesis, melatonin metabolism and melatonin receptor pathway related indicators. Performed to explore the effects of different intensities of geomagnetism on CUMS rats and the related molecular mechanisms.
Results:
The reults showed moderate geomagnetic storms (50 nT) protected against depressive behaviors in CUMS rats by increasing melatonin synthesis and metabolism and MT1 receptor pathway activity, while a extreme geomagnetic storms (500 nT) and shielding from geomagnetic storms (0 nT) inhibited melatonin synthesis and metabolism and the MT1 receptor pathway and aggravated injury.
Conclusions:
In this study we found moderate geomagnetic storms (50 nT) protected against depressive behaviors in CUMS rats, while a extreme geomagnetic storms (500 nT) and shielding from geomagnetic storms (0 nT) aggravated injury.
Related Concept Videos
Depression: Overview
Electroconvulsive Therapy
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Mania and Antimanic Drugs: Overview
Bipolar Disorder
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...


