Leontopodium species: Phytochemistry, biosynthesis, synthesis, pharmacology, and synthetic advancement
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View abstract on PubMed
Summary
This summary is machine-generated.Leontopodium, a genus of medicinal plants, offers potent antioxidant and skin protection. This review details its phytochemistry, pharmacology, and synthesis, highlighting key compounds like leolignin for health benefits.
Area Of Science
- Phytochemistry
- Medicinal Botany
- Organic Synthesis
Background
- Leontopodium (daisy family) is recognized for medicinal properties, including antioxidant and skin protection.
- A comprehensive overview of Leontopodium's various aspects is currently lacking.
- This genus contains diverse phytochemicals with significant biological activities.
Purpose Of The Study
- To provide a state-of-the-art review of Leontopodium.
- To cover its phytochemistry, biosynthesis, synthesis, pharmacology, and synthetic advancements.
- To consolidate current knowledge for researchers and industry professionals.
Main Methods
- Extensive literature search using PubMed, Web of Science, and SCI-Finder.
- Data collection from the 1970s to the present.
- Focus on the keyword "Leontopodium" for literature retrieval.
Main Results
- Identified 179 diverse phytochemicals, including flavonoids, phenolic acids, terpenoids, phthalides, lignans, and coumarins.
- Leontopodium constituents exhibit anti-inflammatory, antioxidant, and organ-protective effects.
- Biosynthesis and synthesis pathways for several metabolites were proposed, with leolignin showing pharmacological relevance.
Conclusions
- Leontopodium compounds possess valuable medicinal properties, particularly for anti-inflammation and antioxidant activity.
- Synthetic advancements in leolignin derivatives show promise for cardioprotective and farnesoid X receptor (FXR) agonistic effects.
- Further clinical studies are warranted to fully explore the therapeutic potential of Leontopodium.
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